Neuronal Intranuclear Inclusions in Polyglutamine Diseases
نویسندگان
چکیده
منابع مشابه
Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child.
Neuronal intranuclear inclusion disease (NIID) is a rare and heterogeneous group of slowly progressive neurodegenerative disorders characterized by the widespread presence of eosinophilic neuronal intranuclear inclusions (NII) accompanied by a more restricted pattern of neuronal loss. We report here the pathologic findings in a 13-year-old boy who died after a 6-year clinical history of progres...
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BACKGROUND Many cases of frontotemporal dementia (FTD) are familial, often with an autosomal dominant pattern of inheritance. Some are due to a mutation in the tau- encoding gene, on chromosome 17, and show an accumulation of abnormal tau in brain tissue (FTDP-17T). Most of the remaining familial cases do not exhibit tau pathology, but display neuropathology similar to patients with dementia an...
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ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80581-4